Purified anti-human CD77 Antibody anti-CD77 - 5B5,BioLegend,357102

Additional reported applications (for relevant formats) include: Western blotting1and immunohistochemical staining of frozen tissue sections1.

Host

Mouse

Reactivity

Human

Application

FC -Quality testedWB, IHC-F -Reported in the literature, not verified in house

Platform ID

BAB253601415

BioLegend

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NamePurified anti-human CD77 Antibody anti-CD77 - 5B5
Cat. No.357102
HostMouse
RRIDAB_2561846 (BioLegend Cat. No. 357101)AB_2561847 (BioLegend Cat. No. 357102)
IsotypeMouse IgM, κ
ReactivityHuman
ApplicationFC -Quality testedWB, IHC-F -Reported in the literature, not verified in house
ClonalityMonoclonal
Clone Number5B5
Concentration0.5 mg/ml
ImmunogenHuman peripheral blood mononuclear cells
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only

Scientific Background

CD77 is also known as Gb3 glycosphingolipid. It was found specifically expressed on Burkitt's lymphoma cells and on a subset of germinal center B lymphocytes. CD77 has been described as a receptor for Shiga Toxin and Verotoxin 1 (VT1), which is produced byShigella dysenteriaeand some strains ofE. coli. It is used as a marker for germinal center stage B-cells. CD19 has been reported as a ligand for CD77 and their interaction functions in adhesion and signal transduction at a specific stage of B cell development. Studies have shown that cross-linking CD77 induces apoptosis in some B cell lines.

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