Purified anti-human CD86 Antibody anti-CD86 - BU63,BioLegend,374202

Host

Mouse

Reactivity

Human

Application

FC -Quality testedBlocking, IP, WB -Reported in the literature, not verified in house

Platform ID

BAB774341455

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

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Product Specifications
Scientific Background

Specifications

NamePurified anti-human CD86 Antibody anti-CD86 - BU63
Cat. No.374202
HostMouse
RRIDAB_2687347 (BioLegend Cat. No. 374202)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationFC -Quality testedBlocking, IP, WB -Reported in the literature, not verified in house
ClonalityMonoclonal
Clone NumberBU63
Concentration0.5 mg/ml
TargetCD86
ImmunogenARH 77 (B lymphoblastoid cell line).
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only

Scientific Background

CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, monocytes/macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is the ligand of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce costimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can bind to CD152 as well, also known as CTLA-4, to deliver an inhibitory signal to T cells.

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