Purified anti-human GP6 Antibody, GP6, HY101,BioLegend,383802

Glycoprotein VI (GPVI) is a 37 kD type-I transmembrane glycoprotein of the immunoglobulin superfamily, primarily expressed on platelets and megakaryocytes. GPVI is a collagen receptor and is involved in collagen-induced platelet adhesion and activation. GPVI plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.