Purified anti-human/mouse CD3epsilon activation epitope Antibody anti-CD3e - APA1/1,BioLegend,362701
Clone APA1/1 recognizes an activation-dependent intracellular epitope of the CD3ε chain. Additional reported applications (for the relevant formats of this clone) include: immunofluorescent staining of paraformaldehyde fixed sections1,in vivotracking of T cells2, and Western blotting3. The LEAF purified format is recommended forin vivostudies.
Host
Mouse
Reactivity
Human, Mouse
Application
ICFC -Quality testedWB, IHC-P -Verifiedin vivo cell tracking -Reported in the literature, not verified in houseICC, IHC, IP -Reported by the developer, not verified in house
Platform ID
BAB026043109
BioLegend
Contact
Tel: 1-858-455-9588
Fax: +49 (4131) 7023913
Email:
Specifications
Scientific Background
The CD3ε chain of the CD3-TCR complex is a type I membrane protein that undergoes conformational change following ligation of the TCR-CD3 complex. This conformational change leads to exposure of the proline rich sequence in CD3ε and results in recruitment of Nck. It is expressed by all mature T cells and forms a heteromeric complex with CD3 α/β or γ/δ and ζ chains. It is important in T cell development, and deficiency of this gene has been associated with severe immunodeficiency.
Category Paths
- Products>Primary Antibodies>IHC Antibodies
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