Purified anti-mouse CD106 Antibody anti-CD106 - 429 (MVCAM.A),BioLegend,105701

Additional reported applications (for the relevant formats) include: immunohistochemical staining2,3,5-7of acetone-fixed frozen sections, blocking4,5,8of ligand bindingin vitroandin vivo, immunoprecipitation1, and spacial biology (IBEX)11,12. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 105727 & 105728).

Host

Rat

Reactivity

Mouse

Application

FC -Quality testedIHC-F, IP -Reported in the literature, not verified in house

Platform ID

BAB622092041

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

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Product Specifications
Scientific Background

Specifications

NamePurified anti-mouse CD106 Antibody anti-CD106 - 429 (MVCAM.A)
Cat. No.105701
HostRat
RRIDAB_313202 (BioLegend Cat. No. 105701)AB_313203 (BioLegend Cat. No. 105702)
IsotypeRat IgG2a, κ
ReactivityMouse
ApplicationFC -Quality testedIHC-F, IP -Reported in the literature, not verified in house
ClonalityMonoclonal
Clone Number429 (MVCAM.A)
Concentration0.5 mg/ml
TargetCD106
ImmunogenMouse preadipose cell line PA6
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only

Scientific Background

CD106 is a 110 kD glycosylphosphatidylinositol (GPI)-linked transmembrane protein, also known as VCAM-1 and INCAM-110. It is constitutively expressed on bone marrow stromal cells, myeloid progenitors, splenic dendritic cells, activated endothelial cells, as well as some lymphocytes. CD106 expression can be upregulated on endothelial cells by inflammatory cytokines. CD106 is involved in adhesion and acts as a counter-receptor for VLA-4 (α4/β1integrin) and LPAM-1 (α4/β7integrin). The 429 antibody has been reported to partially block VCAM-1-mediated binding.

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