Purified anti-mouse CD107b Mac-3 Antibody anti-Mac-3 - M3/84,BioLegend,108502

Additional reported applications (for the relevant formats) include: immunoprecipitation1-4and immunohistochemical staining of acetone-fixed frozen sections5,6and paraformaldehyde-fixed paraffin-embedded sections9-11.

Host

Rat

Reactivity

Mouse

Application

FC -Quality testedIP, ICC, IHC-P, IHC-F -Reported in the literature, not verified in house

Platform ID

BAB561198755

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Product Specifications
Scientific Background

Specifications

NamePurified anti-mouse CD107b Mac-3 Antibody anti-Mac-3 - M3/84
Cat. No.108502
HostRat
RRIDAB_313382 (BioLegend Cat. No. 108501)AB_313383 (BioLegend Cat. No. 108502)
IsotypeRat IgG1, κ
ReactivityMouse
ApplicationFC -Quality testedIP, ICC, IHC-P, IHC-F -Reported in the literature, not verified in house
ClonalityMonoclonal
Clone NumberM3/84
Concentration0.5 mg/ml
TargetCD107b
ImmunogenMembrane glycoproteins from C57BL/6 mouse peritoneal exudate cells
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only

Scientific Background

Mac-3 is a 110 kD type I membrane glycoprotein, also known as CD107b and LAMP-2. It is expressed on lysosomal membranes and the plasma membrane of macrophages and some myeloid cell lines. In the bone marrow, few cells display Mac-3 antigen on the surface, but a large proportion express Mac-3 in the cytoplasm. CD107b has been identified as a ligand for galaptin, an S-type lectin present in the extracellular matrix. Mac-3/CD107b is upregulated in some tumors and increased expression has been correlated with enhanced metastatic potential.

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