Purified anti-mouse CD172a SIRPalpha Antibody anti-CD172a - P84,BioLegend,144001
Additional reported applications (for the relevant formats) include: blocking SIRPa interaction with CD474,in vivoblocking of dendritic cell migration3, enhancing of macrophage phagocytosis2,4, immunohistochemical staining of cerebellum frozen sections1, immunoprecipitation2,4, and spatial biology (IBEX)5,6.
Host
Rat
Reactivity
Mouse
Application
FC -Quality testedIHC-F, IP, Block -Reported in the literature, not verified in house
Platform ID
BAB202903233
BioLegend
Contact
Tel: 1-858-455-9588
Fax: +49 (4131) 7023913
Email:
Specifications
Scientific Background
CD172a, also known as SIRPα, is a type I transmembrane protein with one V-set Ig-like and two C-set Ig-like domains in the extracellular portion, and two ITIM motifs and a proline-rich region in the cytoplasmic tail. CD172a is expressed by monocytes, macrophages, myeloid cells, and neuronal tissue. The phosphorylation of SIRPα ITIMs induces the recruitment and activation of the tyrosine phosphatases PTPN6 and PTPN11, resulting in the negative regulation of several biological processes. The ligands of CD172a are CD47, SP-A, and SP-D.
Category Paths
- Products>Primary Antibodies>IHC Antibodies
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