Purified anti-mouse CD279 PD-1 Antibody anti-CD279 - 29F.1A12,BioLegend,135202
Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue3,in vivoblocking of PD-1 binding to its ligands2,3, and spatial biology (IBEX)5,6.
Host
Rat
Reactivity
Mouse
Application
FC -Quality testedIHC-F -VerifiedBlock -Reported in the literature, not verified in house
Platform ID
BAB362671565
BioLegend
Contact
Tel: 1-858-455-9588
Fax: +49 (4131) 7023913
Email:
Specifications
Scientific Background
CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.
Category Paths
- Products>Primary Antibodies>IHC Antibodies
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