Purified anti-mouse CD8a Antibody anti-CD8a - 5H10-1,BioLegend,100801
Additional reported applications (for the relevant formats) include: partial inhibition of T-cell responses to IL-2 and cytotoxic induction of splenic T cells1, immunohistochemistry of acetone-fixed frozen sections2, and immunofluorescence. The 5H10-1 antibody competes with 53-6.7 antibody (Cat. No. 100702) for binding to thymocytes1.Clone 5H10-1 is not recommended for immunohistochemistry of formalin-fixed paraffin sections.
Host
Rat
Reactivity
Mouse
Application
FC -Quality testedICC -VerifiedIHC-F -Reported in the literature, not verified in house
Platform ID
BAB817831834
BioLegend
Contact
Tel: 1-858-455-9588
Fax: +49 (4131) 7023913
Email:
Specifications
Scientific Background
CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.
Category Paths
- Products>Primary Antibodies>IHC Antibodies
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