Purified anti-mouse LPAM-1 Integrin alpha4beta7 Antibody anti-LPAM-1 - DATK32,BioLegend,120602
Additional reported applications (for the relevant formats) include:in vitroandin vivoblocking of cell adhesion1-4,in vitroinduction of TK1 cell aggregation1, immunoprecipitation4, and immunohistochemical staining of frozen sections5. It has been reported that the DATK32 mAb is able to block a4ß7 mediated lymphocyte adhesion to VCAM-1, MAdCAM-1, and fibronectinin vitroandin vivo.
Host
Rat
Reactivity
Mouse
Application
FC -Quality testedBlock, IP, IHC-F -Reported in the literature, not verified in house
Platform ID
BAB905401045
BioLegend
Contact
Tel: 1-858-455-9588
Fax: +49 (4131) 7023913
Email:
Specifications
Scientific Background
DATK32 antibody is specific for a combinatorial determinate of integrin α4β7complex. Integrin α4β7 is composed of a 150 kD (α4 or CD49d) and a 130 kD (β7) heterodimer, also known as CD49d/β7 or LPAM-1. Belonging to the Ig superfamily, it is found on the majority of peripheral lymphocytes and subsets of thymocytes and bone marrow cells (including mast cell progenitors). Integrin α4β7 binds its ligands, VCAM-1 (CD106), MAdCAM-1 and fibronectin, and plays an important role in lymphocytes adhesion and the direction of migration of blood lymphocytes to the intestine and associated lymphoid tissues.
Category Paths
- Products>Primary Antibodies>IHC Antibodies
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