Purified anti-mouse/human CD15 SSEA-1 Antibody anti-SSEA-1 - MC-480,BioLegend,125602
Additional reported applications (for the relevant formats) include: immunoprecipitation1, Western blotting1, and immunohistochemistry1of acetone-fixed frozen tissue sections and formalin-fixed paraffin-embedded sections.
Host
Mouse
Reactivity
Human, Mouse
Application
FC -Quality testedIP, WB, IHC-F, IHC-P -Reported in the literature, not verified in house
Platform ID
BAB126228790
BioLegend
Contact
Tel: 1-858-455-9588
Fax: +49 (4131) 7023913
Email:
Specifications
Scientific Background
The MC-480 antibody reacts with mouse and human Stage-Specific Embryonic Antigen-1 (SSEA-1). It is a Lewis blood group related carbohydrate antigen, also known as X-hapten, Lewis X, 3-FAL, 3-fucosyl-N-acetyllactosamine, or CD15. The expression pattern of SSEA-1 antigen is different in humans than in mice. In mice, SSEA-1 is expressed on embryonic stem cells (ES), embryonal carcinoma cells (EC), 8-cell to blastocyst embryos, and a subset of embryonic inner cell mass. The expression on murine ES cells is decreased upon differentiation. In humans, however, SSEA-1 is not found on undifferentiated ES cells, but its expression is upregulated along with differentiation. CD15 is highly expressed on adult human granulocytes. It has been reported that SSEA-1 plays a role in cell adhesion and regulation of cell differentiation.
Category Paths
- Products>Primary Antibodies>IHC Antibodies
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