Purified anti-mouse/rat CD49e Antibody anti-CD49e - HMα5-1,BioLegend,103902
Additional reported applications (for the relevant formats) include: immunoprecipitation1,in vivoinhibition of fibronectin receptor (VLA-5) functions andin vitroblocking of CD49e mediated interactions1,2. The Ultra-LEAF™ Purified antibody (Endotoxin <0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 103909 & 103910).
Host
Armenian Hamster
Reactivity
Mouse, Rat
Application
FC - Quality testedIP - Reported in the literature, not verified in house
Platform ID
BAB486523352
BioLegend
Contact
Tel: 1-858-455-9588
Fax: +49 (4131) 7023913
Email:
Specifications
Scientific Background
CD49e is a 135 kD protein, also known as α5integrin or VLA-5 α chain. It is a member of the integrin family, expressed on thymocytes, pro-B cells, activated T cells, and mast cells. CD49e associates with CD29 (integrin β1chain) to form the fibronectin receptor (VLA-5). CD49e plays a critical role in both adhesion and T cell costimulation. The primary ligand for CD49e/CD29 (VLA-5) is fibronectin. The HMα5-1 antibody has been shown to partially block CD49e mediated interactions. It has also been observed that plate-bound HMα5-1 antibody enhances IgE mediated degranulation and thatin vivoinjection of HMα5-1 antibody, in combination with anti-CD49d and anti-CD61 antibodies, blocks passive cutaneous anaphylaxis.
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- Products>Primary Antibodies>Monoclonal Antibodies
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