Purified anti-mouse/rat beta-Amyloid, 1-16 Antibody anti-beta-Amyloid, 1-16 - M3.2,BioLegend,805707

Clone M3.2 recognizes a rodent sequence of Aß, ß-CTF, sAPP-a, and full length APP. Clone 3.2 has negligible cross reactivity with human isoforms of APP and beta amyloid.

Host

Mouse

Reactivity

Mouse, Rat

Application

WB -Quality testedICC, IP, ELISA Detection, ELISA Capture -Reported in the literature, not verified in house

Platform ID

BAB811023839

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Headquarters

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NamePurified anti-mouse/rat beta-Amyloid, 1-16 Antibody anti-beta-Amyloid, 1-16 - M3.2
Cat. No.805707
HostMouse
RRIDAB_2734556 (BioLegend Cat. No. 805707)AB_2564982 (BioLegend Cat. No. 805701)AB_2564981 (BioLegend Cat. No. 805702)
IsotypeMouse IgG1, κ
ReactivityMouse, Rat
ApplicationWB -Quality testedICC, IP, ELISA Detection, ELISA Capture -Reported in the literature, not verified in house
ClonalityMonoclonal
Clone NumberM3.2
Concentration1 mg/ml
Targetbeta-Amyloid 1-16
ImmunogenThe epitope has been determined to be within residues 10-15 of murine Aβ.
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution.
StorageThis antibody should be handled aseptically as it is free of preservatives such as Sodium Azide. Store this antibody undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check the vial label orCoAto find the proper storage conditions.
Regulatory StatusResearch Use Only

Scientific Background

Alzheimer's disease is characterized by the accumulation of aggregated Aβ peptides in senile plaques and vascular deposits. Aβ peptides are derived from amyloid precursor proteins (APP) through sequential proteolytic cleavage of APP by β-secretases and γ-secretases generating diverse Aβ species. Aβ can aggregate to form soluble oligomeric species and insoluble fibrillar or amorphous assemblies. Some forms of the aggregated peptides are toxic to neurons.

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