Pyruvate dehydrogenase kinase 1 / PDK1 antibody,Genetex,GTX22495

PDK 1 (3-Phosphoinositide-Dependant Protein Kinase 1) phosphorylates AGC kinases. PDK 1 activates conventional PKC and PKCz (zeta) through phosphorylation of critical threonine residues in the activation loop. PDK 1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.

pyruvate dehydrogenase kinase 1