QSER1 (F6Z3K) Rabbit Monoclonal Antibody#25444,Cell Signaling Technology (CST),25444

QSER1 (F6Z3K) Rabbit Monoclonal Antibody recognizes endogenous levels of total QSER1 protein. This antibody detects isoform 1 and isoform 2 of QSER1.

Host

Rabbit

Reactivity

Human, Rat, Monkey

Application

Western Blotting: 1:1000 Immunoprecipitation: 1:100 Chromatin IP: 1:50

Platform ID

BAB379107350

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameQSER1 (F6Z3K) Rabbit Monoclonal Antibody#25444
Cat. No.25444
Accession NumberQ2KHR3
Gene ID (Entrez)79832
HostRabbit
SensitivityEndogenous
ReactivityHuman, Rat, Monkey
ApplicationWestern Blotting: 1:1000 Immunoprecipitation: 1:100 Chromatin IP: 1:50
Molecular Weight250
ImmunogenIgG
FormulationFor optimal ChIP results, use 10 μL of antibody and 10 μg of chromatin (approximately 4 × 106cells) per IP. This antibody has been validated using SimpleChIP®Enzymatic Chromatin IP Kits.
StorageSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C.Do not aliquot the antibody.
Regulatory StatusResearch Use Only

Scientific Background

The glutamine and serine-rich protein 1 (QSER1) gene is located on human chromosome 11. A single nucleotide polymorphism (SNP) near theQSER1locus has been associated with older age onset Parkinson’s disease through genome-wide association studies (1), and exome sequencing has suggested QSER1 could potentially serve as a marker of type 2 diabetes (2). More recently, it was shown that QSER1 cooperates with TET1 to protect DNA methylation valleys fromde novomethylation mediated by DNMT3 (3). Recent reports have also found that QSER1 tends to be upregulated in multiple cancers, and this upregulation is associated with poor clinic outcomes (4,5).Latourelle, J.C. et al. (2009)BMC Med Genet10, 98.Barbitoff, Y.A. et al. (2018)Genes (Basel)9, 415. doi: 10.3390/genes9080415.Dixon, G. et al. (2021)Science372, eabd0875. doi: 10.1126/science.abd0875.Dufresne, J. et al. (2019)Clin Proteomics16, 43.Zhao, X. et al. (2023)Cell Death Differ30, 779-793.Alternate NamesFLJ21924; glutamine and serine rich 1; Glutamine and serine-rich protein 1; QSER1

Synonyms

FLJ21924; glutamine and serine rich 1; Glutamine and serine-rich protein 1; QSER1

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