RBM25 (F9X4K) Rabbit Monoclonal Antibody#69882,Cell Signaling Technology (CST),69882

RBM25 is an RNA-binding protein involved in alternative splicing of a large number of transcripts (1,2). RBM25 contributes to splicing by binding splicing factor SRSF2, a process that is blocked by the methylation of RBM25 on Lys77 (2). In various cancer contexts, RBM25 can act as a tumor suppressor. It is capable of selecting for a proapoptotic variant of BCL-x, and can control the Mac inhibitor BIN1 (1,3). In other cancer types, such as hepatocellular carcinoma (HCC), high RBM25 expression has been shown to be associated with poor prognosis (4). RBM25 is also involved in cardiac processes by abnormally splicing SCN5A, truncating it to a form associated with sudden cardiac failure (5,6). In Alzheimer’s disease (AD), RBM25 can form aggregates with the U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) and localize to neurofibrillary Tau aggregates (7).Zhou, A. et al. (2008)Mol Cell Biol28, 5924-36.Carlson, S.M. et al. (2017)J Biol Chem292, 13381-13390.Ge, Y. et al. (2019)Nat Commun10, 172.Zhang, Y.F. et al. (2021)Bioengineered12, 1202-1211.Gao, G. et al. (2011)Circulation124, 1124-31.Gao, G. and Dudley, S.C. (2013)Trends Cardiovasc Med23, 5-8.Bishof, I. et al. (2018)J Biol Chem293, 11047-11066.Alternate NamesArg/Glu/Asp-rich protein of 120 kDa; Arg/Glu/Asp-rich protein, 120 kDa; fSAP94; functional spliceosome-associated protein 94; MGC105088; MGC117168; NET52; Protein S164; RBM25; RED120; RNA binding motif protein 25; RNA-binding motif protein 25; RNA-binding protein 25; RNA-binding region (RNP1, RRM) containing 7; RNA-binding region-containing protein 7; RNPC7; S164; Snu71; U1 small nuclear ribonucleoprotein 1SNRP homolog

Arg/Glu/Asp-rich protein of 120 kDa; Arg/Glu/Asp-rich protein, 120 kDa; fSAP94; functional spliceosome-associated protein 94; MGC105088; MGC117168; NET52; Protein S164; RBM25; RED120; RNA binding motif protein 25; RNA-binding motif protein 25; RNA-binding protein 25; RNA-binding region (RNP1, RRM) containing 7; RNA-binding region-containing protein 7; RNPC7; S164; Snu71; U1 small nuclear ribonucleoprotein 1SNRP homolog