RNF144B antibody [9H10],Genetex,GTX83704

Host

Mouse

Reactivity

Human

Application

WB ICC/IF IHC-P FCM

Conjugate

Unconjugated

Platform ID

BAB256511282

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameRNF144B antibody [9H10]
Cat. No.GTX83704
Gene ID (Entrez)255488
HostMouse
IsotypeIgG2b
ReactivityHuman
ConjugationUnconjugated
ApplicationWB ICC/IF IHC-P FCM
ClonalityMonoclonal
Concentration0.8 mg/ml (Please refer to the vial label for the specific concentration.)
TargetRNF144B
ImmunogenHuman recombinant protein fragment corresponding to amino acids 1-256 of human RNF144B (NP_877434) produced in E. coli.
PurityPurified by affinity chromatography
Appearance/FormLiquid
FormulationPBS, 1% BSA, 50% Glycerol,0.02% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a TP53/p53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death | But, it is not an anti-apoptotic protein per se.

Synonyms

ring finger protein 144B , IBRDC2 , PIR2 , bA528A10.3 , p53RFP

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