ROCK1 + ROCK2 antibody [GT464],Genetex,GTX629972

Host

Mouse

Reactivity

Human, Mouse, Rat

Application

WB

Conjugate

Unconjugated

Platform ID

BAB956910102

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameROCK1 + ROCK2 antibody [GT464]
Cat. No.GTX629972
Gene ID (Entrez)6093
HostMouse
IsotypeIgG2b
ReactivityHuman, Mouse, Rat
ConjugationUnconjugated
ApplicationWB
ClonalityMonoclonal
Concentration1 mg/ml (Please refer to the vial label for the specific concentration.)
TargetROCK1 9475
ImmunogenRecombinant protein encompassing a sequence within the N-terminus region of human ROCK1. The exact sequence is proprietary.
PurityAffinity purified by Protein G.
Appearance/FormLiquid
FormulationPBS,No preservatives
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq]

Synonyms

Rho associated coiled-coil containing protein kinase 1 , P160ROCK , ROCK-I

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.