RPE65 antibody [401.8B11.3D9],Genetex,GTX13826

Host

Mouse

Reactivity

Human, Mouse, Rat, Bovine, Dog, Chicken, Pig, Xenopus

Application

WB ICC/IF IHC-P IHC-Fr FCM MS

Conjugate

Unconjugated

Platform ID

BAB475673620

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameRPE65 antibody [401.8B11.3D9]
Cat. No.GTX13826
Gene ID (Entrez)282043
HostMouse
IsotypeIgG1
ReactivityHuman, Mouse, Rat, Bovine, Dog, Chicken, Pig, Xenopus
ConjugationUnconjugated
ApplicationWB ICC/IF IHC-P IHC-Fr FCM MS
ClonalityMonoclonal
Concentration1 mg/ml (Please refer to the vial label for the specific concentration.)
TargetRPE65
ImmunogenBovine RPE65 microsomal membrane proteins. [UniProt# Q28175]
PurityProtein G purified
Appearance/FormLiquid
FormulationPBS,0.05% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association.

Synonyms

retinoid isomerohydrolase RPE65

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