RPL7A Antibody (YA2859),MedChemexpress,HY-P83114

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. The related gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. The related gene is included in the surfeit related gene cluster, a group of very tightly linked related genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA related genes, which are located in its second, fifth, fourth, and sixth introns, respectively. The related gene rearranges with the trk proto-oncorelated gene to form the chimeric oncorelated gene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for related genes encoding ribosomal proteins, there are multiple processed pseudorelated genes of The related gene dispersed through the genome.

PLA X polypeptide; RP23-414L19.4; RPL7A; SURF3; surfeit 3; TRUP