RUNX2 Antibody (YA085),MedChemexpress,HY-P80316

RUNX2 Antibody (YA085) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RUNX2.

Host

Rabbit

Reactivity

Human,Mouse

Application

ICC/IF,IHC-P,WB

Conjugate

Non-conjugated

Platform ID

BAB189536320

Suppliers

(1)

Biomedical Life sciences

91-9676853503

[email protected]
Country:India
City:Madīnat Ḩamad
Plot No.A-2811121/A&B/3.IP NACHARAM. ALA NACHARAM, Road N0-15, Hyderabad Medchal Malkajgiri, Telangana-500076
Master of Bioactive Molecules

MedChemexpress

Master of Bioactive Molecules

Headquarters

1 Deer Park Drive, Suite FMONMOUTH JUNCTION, NI 08852, USA

MedChemexpress

Contact

Tel: 609-228-6898
Fax: 609-228-5909

Email:

[email protected]

Product Specifications
Verification Image
Scientific Background

Specifications

NameRUNX2 Antibody (YA085)
Cat. No.HY-P80316
Accession NumberQ13950
Gene ID (Entrez)860
HostRabbit
RRIDAB_3102423
IsotypeIgG
SensitivityEndogenous
ReactivityHuman,Mouse
ConjugationNon-conjugated
ApplicationICC/IF,IHC-P,WB
Working DilutionsWB: 1:500; ICC/IF: 1:50-1:200; IHC-P: 1:50-1:500
ClonalityRecombinant,Monoclonal
Clone NumberYA085
Molecular WeightPredicted band size: 57 kDa; Observed band size: 57 kDa
ImmunogenSynthetic peptide corresponding to Human RUNX2.AA range:300-450.
PurityProtein A affinity purified.
Appearance/FormLiquid
ShippingShipping with blue ice.
FormulationSupplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
StorageStored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Regulatory StatusResearch Use Only

Verification Image

Scientific Background

RUNX2 is a transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. It is essential for osteoblast maturation as well as both intramembranous and endochondral ossification. CBF binds to the core site 5'-PYGPYGGT-3' of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3, and GM-CSF promoters. In osteoblasts, RUNX2 supports transcriptional activation by synergizing with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (by similarity). It also inhibits KAT6B-dependent transcriptional activation.

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.