Rab7 (D95F2) Rabbit Monoclonal Antibody (Alexa Fluor^®647 Conjugate)#94298,Cell Signaling Technology (CST),94298

Rab7 and Rab9 are members of the Ras superfamily of small Rab GTPases (1). Both proteins are located in late endosomes, but exert different functions. Rab7 associates with the RIPL effector protein to control membrane trafficking from early to late endosomes and to lysosomes (2,3). Rab7 also helps to regulate growth receptor endocytic trafficking and degradation (3,4), and maturation of phagosome and autophagic vacuoles (4-6). Rab9 interacts with its effector proteins p40 and TIP47 (7,8) to promote the MPR (mannose 6-phosphate receptor)-associated lysosomal enzyme transport between late endosomes and the trans Golgi network (9,10).Zerial, M. and McBride, H. (2001)Nat Rev Mol Cell Biol2, 107-17.Feng, Y. et al. (1995)J Cell Biol131, 1435-52.Méresse, S. et al. (1995)J Cell Sci108 (Pt 11), 3349-58.Ceresa, B.P. and Bahr, S.J. (2006)J Biol Chem281, 1099-106.Jäger, S. et al. (2004)J Cell Sci117, 4837-48.Méresse, S. et al. (1999)EMBO J18, 4394-403.Díaz, E. et al. (1997)J Cell Biol138, 283-90.Barbero, P. et al. (2002)J Cell Biol156, 511-8.Lombardi, D. et al. (1993)EMBO J12, 677-82.Riederer, M.A. et al. (1994)J Cell Biol125, 573-82.Alternate NamesCMT2B; FLJ20819; PRO2706; RAB7; RAB7, member RAS oncogene family; RAB7A; RAB7A, member RAS oncogene family; Ras-associated protein RAB7; Ras-related protein Rab-7a

CMT2B; FLJ20819; PRO2706; RAB7; RAB7, member RAS oncogene family; RAB7A; RAB7A, member RAS oncogene family; Ras-associated protein RAB7; Ras-related protein Rab-7a