Rad50 antibody [13B3],Genetex,GTX70228

Host

Mouse

Reactivity

Human, Mouse, Rat, Monkey

Application

WB ICC/IF IHC-P IP ChIP assay IHC in vitro PLA

Conjugate

Unconjugated

Platform ID

BAB234621794

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameRad50 antibody [13B3]
Cat. No.GTX70228
Gene ID (Entrez)10111
HostMouse
IsotypeIgG1
ReactivityHuman, Mouse, Rat, Monkey
ConjugationUnconjugated
ApplicationWB ICC/IF IHC-P IP ChIP assay IHC in vitro PLA
ClonalityMonoclonal
Concentration1 mg/ml (Please refer to the vial label for the specific concentration.)
TargetRAD50
ImmunogenAmino acids 1-425 of Rad50 expressed in E. coli.
PurityAffinity purified by Protein G.
Appearance/FormLiquid
FormulationPBS,No preservatives
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010]

Synonyms

RAD50 double strand break repair protein , NBSLD , RAD502 , hRad50

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