SF3A1 (F8X7A) Rabbit Monoclonal Antibody#41169,Cell Signaling Technology (CST),41169

The mammalian splicing factor SF3a contains three primary subunits: SF3A1 (SF3a120), SF3A2 (SF3a66), and SF3A3 (SF3a60), which, along with SF3b, activate the U2 snRNP to form the pre-mRNA splicing complex (1,2). SF3A2 and SF3A3 interact with SF3A1, but not with each other, and SF3A3 plays a major role in recruiting SF3A1 to the complex (3). Each protein in the heterotrimer has been shown to be essential for mRNA splicing and cell viability (4). Notably, SF3a plays a role in growth factor signaling as SF3A1 can bind to ERα when phosphorylated at Ser118 to affect downstream splicing (5). SF3a also plays a role in the innate immune response, promoting inflammation by splicing the TLR adaptor Myd88. Furthermore, SF3a regulates several genes involved in innate immune signaling pathways in macrophages versus other pathways (6,7).Brosi, R. et al. (1993)Science262, 102-5.Brosi, R. et al. (1993)J Biol Chem268, 17640-6.Nesic, D. and Krämer, A. (2001)Mol Cell Biol21, 6406-17.Tanackovic, G. and Krämer, A. (2005)Mol Biol Cell16, 1366-77.Masuhiro, Y. et al. (2005)Proc Natl Acad Sci USA102, 8126-31.De Arras, L. and Alper, S. (2013)PLoS Genet9, e1003855.O'Connor, B.P. et al. (2015)PLoS Genet11, e1004932.Alternate Namespre-mRNA processing 21; pre-mRNA splicing factor SF3a (120 kDa subunit); PRP21; PRPF21; SAP 114; SAP114; SF3A1; SF3a120; spliceosome associated protein 114; Spliceosome-associated protein 114; splicing factor 3 subunit 1; Splicing factor 3A subunit 1; splicing factor 3a, subunit 1, 120kD; splicing factor 3a, subunit 1, 120kDa

pre-mRNA processing 21; pre-mRNA splicing factor SF3a (120 kDa subunit); PRP21; PRPF21; SAP 114; SAP114; SF3A1; SF3a120; spliceosome associated protein 114; Spliceosome-associated protein 114; splicing factor 3 subunit 1; Splicing factor 3A subunit 1; splicing factor 3a, subunit 1, 120kD; splicing factor 3a, subunit 1, 120kDa