SF3B4 (E7R4H) Rabbit Monoclonal Antibody#68862,Cell Signaling Technology (CST),68862

SF3B4 (E7R4H) Rabbit Monoclonal Antibody recognizes endogenous levels of total SF3B4 protein.

Host

Rabbit

Reactivity

Human, Mouse, Rat, Monkey

Application

Western Blotting: 1:1000 Immunoprecipitation: 1:50

Platform ID

BAB319424747

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameSF3B4 (E7R4H) Rabbit Monoclonal Antibody#68862
Cat. No.68862
Accession NumberQ15427
Gene ID (Entrez)15427, 10262
HostRabbit
SensitivityEndogenous
ReactivityHuman, Mouse, Rat, Monkey
ApplicationWestern Blotting: 1:1000 Immunoprecipitation: 1:50
Molecular Weight48
ImmunogenIgG
FormulationSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C.Do not aliquot the antibody.
StorageSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C.Do not aliquot the antibody.
Regulatory StatusResearch Use Only

Scientific Background

SF3B4 is part of the SF3b complex, which associates with the U2 snRNP component of the spliceosome and is essential for spliceosome assembly (1-3). SF3B4 can associate with BMPR-1A to inhibit BMP-mediated cell differentiation (4). Haploinsufficiency of SF3B4 has been described in Nager syndrome, a disease of craniofacial malformation condition (5,6). Increased copy number of SF3B4 has been shown to play a role in hepatocellular carcinoma progression (7-9).Das, B.K. et al. (1999)Mol Cell Biol19, 6796-802.Brosi, R. et al. (1993)J Biol Chem268, 17640-6.Golas, M.M. et al. (2003)Science300, 980-4.Watanabe, H. et al. (2007)J Biol Chem282, 20728-38.Bernier, F.P. et al. (2012)Am J Hum Genet90, 925-33.Drivas, T.G. et al. (2019)Am J Med Genet A179, 1063-8.Iguchi, T. et al. (2016)Anticancer Res36, 2139-44.Shen, Q. et al. (2018)Hepatology67, 1360-77.Liu, Z. et al. (2018)EBioMedicine38, 57-68.Alternate NamesAFD1; Hsh49; MGC10828; pre-mRNA splicing factor SF3b 49 kDa subunit; Pre-mRNA-splicing factor SF3b 49 kDa subunit; SAP 49; SAP49; SF3B4; SF3b49; SF3b50; spliceosomal protein; spliceosome-associated protein (U2 snRNP); Spliceosome-associated protein 49; Splicing factor 3B subunit 4; splicing factor 3b, subunit 4, 49kD; splicing factor 3b, subunit 4, 49kDa

Synonyms

AFD1; Hsh49; MGC10828; pre-mRNA splicing factor SF3b 49 kDa subunit; Pre-mRNA-splicing factor SF3b 49 kDa subunit; SAP 49; SAP49; SF3B4; SF3b49; SF3b50; spliceosomal protein; spliceosome-associated protein (U2 snRNP); Spliceosome-associated protein 49; Splicing factor 3B subunit 4; splicing factor 3b, subunit 4, 49kD; splicing factor 3b, subunit 4, 49kDa

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