SHP2 (phospho Tyr580) antibody,Genetex,GTX78945

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]

BPTP3,CFC,JMML,METCDS,NS1,PTP1D,PTP2C,PTPN11,SHP2,SHPTP2,SHPTP3,protein tyrosine phosphatase, nonreceptor type 11,protein tyrosine phosphatase non-receptor type 11