SKP1 Recombinant Antibody,Bioss,bsm-61662r

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

WB, Flow-Cyt, ICC/IF

Conjugate

Unconjugated

Platform ID

BAB308206226

Bioss

Headquarters

300 Tradecenter Dr, ste 4610Woburn, Massachusetts 01801 - U.S.A.

Bioss

Contact

Tel: +1.781.569.5821
Fax: +1.781.731.9286

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameSKP1 Recombinant Antibody
Cat. No.bsm-61662r
Accession NumberP63208
Gene ID (Entrez)6500
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat
ConjugationUnconjugated
ApplicationWB, Flow-Cyt, ICC/IF
Working DilutionsWB:1:300-5000 | Flow-Cyt:1ug/Test | ICC/IF:1:50-100
ClonalityRecombinant
ConcentrationLot dependent
PurityPurified by Protein A.
Formulation0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol
StorageShipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Scientific Background

Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2.

Synonyms

OCP2; p19A; EMC19; SKP1A; OCP-II; TCEB1L.

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