SMARCA2 / BRM Rabbit mAb,ABclonal,A23291

Reactivity

Human

Application

WB, IHC-P, IF/ICC, IP, ChIP, ELISA

Conjugate

Unconjugated

Platform ID

BAB531790349

ABclonal

Headquarters

500W Cummings Park, Ste. 6500 Woburn, MA 01801

ABclonal

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Email:

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Product Specifications
Scientific Background
Synonyms

Specifications

NameSMARCA2 / BRM Rabbit mAb
Cat. No.A23291
Accession NumberP51531
Gene ID (Entrez)6595
IsotypeIgG
ReactivityHuman
ConjugationUnconjugated
ApplicationWB, IHC-P, IF/ICC, IP, ChIP, ELISA
Working DilutionsWB:1:500 - 1:2000 | IHC-P:1:200 - 1:800 | IF/ICC:1:50 - 1:200 | IP:0.5μg-4μg antibody for 200μg-400μg extracts of whole cells | ChIP:5μg antibody for 10μg-20μg of Chromatin | ELISA:Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements..
Clone NumberARC59944
Molecular Weight200 kDa
ImmunogenA synthetic peptide corresponding to a sequence within amino acids 201-300 of human SMARCA2 (NP_003061.3).
PurityAffinity purification
Appearance/FormLiquid
StorageStore at -20℃. Avoid freeze / thaw cycles.; Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Regulatory StatusResearch Use Only

Scientific Background

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.

Synonyms

BIS; BRM; SNF2; SWI2; hBRM; NCBRS; Sth1p; BAF190; SNF2L2; SNF2LA; hSNF2a; SMARCA2 / BRM

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