SP1 (D4C3) Rabbit Monoclonal Antibody (PE Conjugate)#74315,Cell Signaling Technology (CST),74315

Specificity protein 1 (SP1) is a ubiquitously expressed transcription factor belonging to the family of C2H2-type zinc finger containing DNA-binding proteins. SP1 binds GC-rich motifs with high affinity and regulates the expression of numerous mammalian genes (1,2). It interacts with many other transcription factors, such as c-Myc, EGR1, and Stat1, and with basal transcription machinery components. SP1 interacts with chromatin-modifying factors, such as histone deacetylases (HDACs) and p300 in chromatin remodeling. Transcriptional activity and stability of SP1 are regulated by post-translational modification, including phosphorylation, acetylation, ubiquitination, and glycosylation (3). Glycosylation of SP1 following insulin treatment leads to increased nuclear localization, while glucagon treatment increases cytoplasmic SP1 levels (4-6). Investigators have found high levels of SP1 in patients with Alzheimer's disease (7).Kadonaga, J.T. et al. (1987)Cell51, 1079-90.Song, J. et al. (2003)Int J Mol Med11, 547-53.Tan, N.Y. and Khachigian, L.M. (2009)Mol Cell Biol29, 2483-8.Majumdar, G. et al. (2003)Am J Physiol Endocrinol Metab285, E584-91.Majumdar, G. et al. (2006)J Biol Chem281, 3642-50.Solomon, S.S. et al. (2008)Life Sci83, 305-12.Citron, B.A. et al. (2008)J Neurosci Res86, 2499-504.Alternate NamesSP1; Sp1 transcription factor; specificity protein 1; Transcription factor Sp1; TSFP1

SP1; Sp1 transcription factor; specificity protein 1; Transcription factor Sp1; TSFP1