SPDEF (F9M9S) Rabbit Monoclonal Antibody#29721,Cell Signaling Technology (CST),29721

SAM pointed domain-containing Ets transcription factor (SPDEF), also known as prostate-derived Ets factor (PDEF), was originally identified as an androgen-independent regulator of prostate-specific antigen (PSA) and binds to 5'-GGAT-3' DNA sequences (1). Expressed primarily in epithelial cells, SPDEF acts as a transcriptional regulator of epithelial cell adhesion, structure, and differentiation. SPDEF is tightly regulated across a variety of cancer types and has been reported as both a tumor oncogene and tumor supressor (2,3). In luminal breast cancer, SPDEF is overexpressed and promotes GALNT7 transcription, increasing tumor cell proliferation and stemness (4). SPDEF suppresses colorectal cancer by inhibiting β-catenin and downstream expression of cyclin D1 and c-Myc (5). Methylation of SPDEF gene enhancer regions by DNA methyltransferases (DNMTs) suppresses SPDEF expression, driving the observed differences in SPDEF transcripts and protein among prostate cancer cell lines and tumor grades (6).Oettgen, P. et al. (2000)J Biol Chem275, 1216-25.Bao, K.C. and Wang, F.F. (2022)Neoplasma69, 1270-1276.Ye, T. et al. (2020)Cancer Manag Res12, 3891-3902.Li, J. et al. (2023)Cell Death Dis14, 569.Noah, T.K. et al. (2013)Gastroenterology144, 1012-1023.e6.Vatanmakanian, M. et al. (2023)Front Endocrinol (Lausanne)14, 1156120.Alternate NamesbA375E1.3; PDEF; Prostate epithelium-specific Ets transcription factor; Prostate-derived Ets factor; Prostate-specific Ets; PSE; RP11-375E1__A.3; SAM pointed domain containing ets transcription factor; SAM pointed domain-containing Ets transcription factor; SPDEF

bA375E1.3; PDEF; Prostate epithelium-specific Ets transcription factor; Prostate-derived Ets factor; Prostate-specific Ets; PSE; RP11-375E1__A.3; SAM pointed domain containing ets transcription factor; SAM pointed domain-containing Ets transcription factor; SPDEF