Sarcomeric alpha Actinin Antibody (YA5771),MedChemexpress,HY-P86079

Sarcomeric alpha Actinin Antibody (YA5771) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Sarcomeric alpha Actinin.

Host

Rabbit

Reactivity

Human,Mouse,Rat

Application

WB,IHC-P,ICC/IF,IP,ELISA

Conjugate

Non-conjugated

Platform ID

BAB848532494

Master of Bioactive Molecules

MedChemexpress

Master of Bioactive Molecules

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Tel: 609-228-6898
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Email:

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Product Specifications
Scientific Background
Synonyms

Specifications

NameSarcomeric alpha Actinin Antibody (YA5771)
Cat. No.HY-P86079
Accession NumberP35609
Gene ID (Entrez)88
HostRabbit
IsotypeIgG
ReactivityHuman,Mouse,Rat
ConjugationNon-conjugated
ApplicationWB,IHC-P,ICC/IF,IP,ELISA
Working DilutionsIHC-P: 1:200-1:1000; WB: 1:500-1:2000; ICC/IF: 1:200-1:1000; ELISA: 1:5000-1:20000; IP: 1:50-1:200
ClonalityMonoclonal
Clone NumberYA5771
Molecular WeightPredicted band size: 104 kDa; Observed band size: 104 kDa
PurityProtein A
Appearance/FormLiquid
ShippingShipping with blue ice.
FormulationSupplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
StorageStored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

Actinin α2 is the principal structural protein of cardiac Z-discs, functioning as an F-actin crosslinking protein that connects actin filaments to TTN filaments and maintains Z-disc integrity (by similar). Unlike Actinin α3 which is exclusively expressed in fast-twitch fibers, Actinin α2 is ubiquitously present in all skeletal and cardiac muscles, participating in mechanotransduction and metabolic regulation through interactions with various Z-disc proteins (e.g., titin, myotilin). Mutations in Actinin α2 are associated with hypertrophic and dilated cardiomyopathies, while the R577X polymorphism of Actinin α3 influences muscle power and endurance performance (by similar).

Synonyms

ACTN2; Alpha-actinin-2; Alpha-actinin skeletal muscle isoform 2; F-actin cross-linking protein

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