Sec24D (D9M7L) Rabbit Monoclonal Antibody#14687,Cell Signaling Technology (CST),14687

Coat Protein Complex II (COPII) is composed of five cytosolic proteins: Sec23/24 complex, Sec13/31 complex, and Sar1. COPII coat is located at the ER/Golgi interface and is involved in transport of newly synthesized proteins from the ER to the Golgi apparatus (1). COPII formation is initiated through the binding of the activated G protein, Sar1, to the Sec23/24 complex, thereby forming a prebudding complex that directly binds target molecules (1-3). The prebudding complex further recruits Sec13/31 to form mature COPII coat (4,5). The Sec24 subunit of COPII coat is thought to play a critical role in cargo selection (2,6). It binds directly to cargo proteins at the ER and brings them to COPII vesicles through interaction with Sec23. There are four Sec24 isoforms in human cells: Sec24A, Sec24B, Sec24C, and Sec24D (7). In mice, mutations in Sec24B have been linked to developmental defects (8,9). Sec24bB has also been identified as a novel regulator of ferroptosis in microglia which can contribute to neurodegeneration (10).Aridor, M. et al. (1998)J Cell Biol141, 61-70.Miller, E.A. et al. (2003)Cell114, 497-509.Mossessova, E. et al. (2003)Cell114, 483-95.Barlowe, C. et al. (1994)Cell77, 895-907.Bi, X. et al. (2007)Dev Cell13, 635-45.Miller, E. et al. (2002)EMBO J21, 6105-13.Tang, B.L. et al. (1999)Biochem Biophys Res Commun258, 679-84.Merte, J. et al. (2010)Nat Cell Biol12, 41-6; sup pp 1-8.Wansleeben, C. et al. (2010)Development137, 1067-73.Ryan, S.K. et al. (2023)Nat Neurosci26, 12-26.Alternate NamesCLCRP2; FLJ43974; KIAA0755; Protein transport protein Sec24D; SC24D; SEC24 family, member D (S. cerevisiae); SEC24 homolog D, COPII coat complex component; SEC24 related gene family, member D; SEC24-related protein D; SEC24D

CLCRP2; FLJ43974; KIAA0755; Protein transport protein Sec24D; SC24D; SEC24 family, member D (S. cerevisiae); SEC24 homolog D, COPII coat complex component; SEC24 related gene family, member D; SEC24-related protein D; SEC24D