Sec31A (E1J5M) Rabbit Monoclonal Antibody#13483,Cell Signaling Technology (CST),13483

The coat protein complex II (COPII) is composed of five cytosolic proteins and includes the Sec23/24 complex, the Sec13/31 complex, and Sar1. The COPII coat is located at the ER/Golgi interface and is involved in transport of newly synthesized proteins from the ER to the Golgi apparatus (1). COPII formation is initiated through the binding of the activated G protein, Sar1, to the Sec23/24 complex to form a pre-budding complex that directly binds target molecules (1-3). This pre-budding complex further recruits Sec13/31 to form mature COPII coat (4,5). The Sec31 subunit of COPII coat interacts with Sec13 at the ER exit and is required for both vesicle formation and ER-Golgi transport. Two isoforms of human Sec31 have been identified, Sec31A and Sec31B, which share a sequence homology of 47.3% (6-8). Sec31A is ubiquitously expressed in tissues and organs, whereas Sec31B is enriched in brain and testis (7,8). In classical Hodgkin lymphoma, a novel fusion of Jak2 with Sec31A renders Jak2 constitutively active and subject to Jak2 inhibitor effects (9).Aridor, M. et al. (1998)J Cell Biol141, 61-70.Miller, E.A. et al. (2003)Cell114, 497-509.Mossessova, E. et al. (2003)Cell114, 483-95.Barlowe, C. et al. (1994)Cell77, 895-907.Bi, X. et al. (2007)Dev Cell13, 635-45.Shugrue, C.A. et al. (1999)J Cell Sci112 ( Pt 24), 4547-56.Tang, B.L. et al. (2000)J Biol Chem275, 13597-604.Stankewich, M.C. et al. (2006)J Cell Sci119, 958-69.Van Roosbroeck, K. et al. (2011)Blood117, 4056-64.Alternate NamesABP125; ABP130; DKFZp686N07171; HSPC275; HSPC334; KIAA0905; MGC90305; NEDSOSB; Protein transport protein Sec31A; protein-transport protein SEC31; SC31A; SEC31 homolog A (S. cerevisiae); SEC31 homolog A, COPII coat complex component; SEC31 homolog A, COPII coating complex component; SEC31-like 1; SEC31-like protein 1; SEC31-related protein A; SEC31A; SEC31L1; Web1-like protein; yeast Sec31p homolog

ABP125; ABP130; DKFZp686N07171; HSPC275; HSPC334; KIAA0905; MGC90305; NEDSOSB; Protein transport protein Sec31A; protein-transport protein SEC31; SC31A; SEC31 homolog A (S. cerevisiae); SEC31 homolog A, COPII coat complex component; SEC31 homolog A, COPII coating complex component; SEC31-like 1; SEC31-like protein 1; SEC31-related protein A; SEC31A; SEC31L1; Web1-like protein; yeast Sec31p homolog