Seladin 1 antibody,Genetex,GTX32863

Host

Rabbit

Reactivity

Human, Rat

Application

WB

Conjugate

Unconjugated

Platform ID

BAB070089543

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameSeladin 1 antibody
Cat. No.GTX32863
Gene ID (Entrez)1718
HostRabbit
IsotypeIgG
ReactivityHuman, Rat
ConjugationUnconjugated
ApplicationWB
ClonalityPolyclonal
ConcentrationBatch dependent (Please refer to the vial label for the specific concentration.)
TargetDHCR24
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 227-516 of human DHCR24 (NP_055577.1).
PurityPurified by affinity chromatography
Appearance/FormLiquid
FormulationPBS, 50% Glycerol,0.02% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]

Synonyms

24-dehydrocholesterol reductase , DCE , Nbla03646 , SELADIN1 , seladin-1

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