Serine/threonine-Protein Kinase Chk1 (CHK1) Antibody,Abbexa,abx015730
CHK1, also known as CHEK1, it is a kinase that phosphorylates cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis.Cdc25, when phosphorylated on serine 216 by CHK1 becomes bound by an adaptor protein in the cytoplasm.Therefore it is inhibited from removing the inhibiting phosphate from MPF (mitotic/maturation promoting factor) added by Wee1.Consequently, a cell is prevented from entering mitosis.CHK1 can also phosphorylate p53 at Ser20 in vitro.
Host
Mouse
Reactivity
Human, Mouse
Application
ELISA, WB
Conjugate
Unconjugated
Platform ID
BAB183004284
Abbexa
Contact
Tel: +44 (0) 1223 755950
Fax: +44 (0) 1223 755951
Email:
Product Specifications
Specifications
NameSerine/threonine-Protein Kinase Chk1 (CHK1) Antibody
Cat. No.abx015730
Gene ID (Entrez)1111
HostMouse
IsotypeIgG1
ReactivityHuman, Mouse
ConjugationUnconjugated
ApplicationELISA, WB
Working DilutionsELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
ClonalityMonoclonal
ConcentrationNot determined.
Molecular Weight56 kDa
ImmunogenPurified recombinant fragment of CHK1 expressed in E. coli.
PurityUnpurified ascites.
Appearance/FormLiquid
FormulationAscitic fluid containing 0.03% sodium azide.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Regulatory StatusResearch Use Only
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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