Smad2 Recombinant Antibody, APC-Cy5.5 Conjugated,Bioss,bsm-52223r-apc-Cy5.5-100ul

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

WB, IF, Flow-Cyt

Conjugate

APC-Cy5.5

Platform ID

BAB335804237

Bioss

Headquarters

300 Tradecenter Dr, ste 4610Woburn, Massachusetts 01801 - U.S.A.

Bioss

Contact

Tel: +1.781.569.5821
Fax: +1.781.731.9286

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameSmad2 Recombinant Antibody, APC-Cy5.5 Conjugated
Cat. No.bsm-52223r-apc-Cy5.5-100ul
Accession NumberQ15796
Gene ID (Entrez)4087
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat
ConjugationAPC-Cy5.5
ApplicationWB, IF, Flow-Cyt
Working DilutionsWB:1:300-5000 | IF: | Flow-Cyt:1ug/Test
ClonalityRecombinant
ConcentrationLot dependent
PurityPurified by Protein A.
FormulationAqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
StorageStore at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Scientific Background

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Synonyms

JV18; MADH2; MADR2; JV18-1; hMAD-2; hSMAD2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; Mad-related protein 2; SMAD family member 2; SMAD 2; Smad2

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