Somatostatin Receptor Antibody Explorer Kit,Alomone Labs,AK-104_KIT

Somatostatin is a small cyclic peptide that is widely expressed throughout the central nervous system and peripheral tissues. 1 In peripheral tissues, somatostatin exerts inhibitory effects on secretion processes, whereas in the brain it acts as a neurotransmitter in both stimulatory and inhibitory manner. 1, 2 Somatostatin mediates its action via six high affinity G-protein coupled receptors (SSTR1, SSTR2a, SSTR2b, SSTR3, SSTR4 and SSTR5) which are encoded by five genes. 1,2 Expression of the different receptors is developmentally regulated in a time and tissue-specific manner. 2 Somatostatin receptors have been found on a variety of neuroendocrine tumors, such as paragangliomas, carcinoids and breast tumors. 3 Synthetic peptide derivatives of somatostatin have been successfully used in the treatment of neuroendocrine malignancies and in in vivo imaging of tumors that are positive to somatostatin receptors. 4