Spark PLUS B550™ anti-human CD366 (Tim-3) Antibody, CD366 (Tim-3), A18087E,BioLegend,364813

Host

Mouse

Reactivity

Human

Application

FC - Quality tested

Platform ID

BAB801217284

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

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Product Specifications
Scientific Background

Specifications

NameSpark PLUS B550™ anti-human CD366 (Tim-3) Antibody, CD366 (Tim-3), A18087E
Cat. No.364813
HostMouse
RRIDAB_3675085 (BioLegend Cat. No. 364813)AB_3675085 (BioLegend Cat. No. 364814)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberA18087E
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCD366
ImmunogenRecombinant human Tim-3
PurityThe antibody was purified by affinity chromatography and conjugated with Spark PLUS B550™ under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.

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