Spark PLUS UV395™ anti-mouse Siglec H Antibody, Siglec H, 551,BioLegend,129621
Host
Rat
Reactivity
Mouse
Application
FC - Quality tested
Platform ID
BAB565008190
BioLegend
Contact
Tel: 1-858-455-9588
Fax: +49 (4131) 7023913
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Product Specifications
Scientific Background
Specifications
NameSpark PLUS UV395™ anti-mouse Siglec H Antibody, Siglec H, 551
Cat. No.129621
HostRat
RRIDAB_3662185 (BioLegend Cat. No. 129621)AB_3662185 (BioLegend Cat. No. 129622)
IsotypeRat IgG1, κ
ReactivityMouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone Number551
Concentration0.2 mg/mL
TargetSiglec H
ImmunogenSiglec-H-Fc recombinant fusion protein
PurityThe antibody was purified by affinity chromatography and conjugated with Spark PLUS UV395™ under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
The Siglec-H is a member of CD33-related Siglec family which mostly expressed in the innate immune system. Siglec-H is reported to be specifically expressed on plasmacytoid dendritic cells. Siglec-H depends on adaptor protein DAP 12 (DNAX-activating protein of 12 kD) for surface expression and signal transduction. Cross-linking with this antibody can selectively inhibit interferon-alpha production by IPCs following TLR9 ligation.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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