Spark PLUS V475™ anti-human CD25 Antibody,BioLegend,385611

Clone S20019C can completely block binding of clone BC96 and clone TÜ69 on target cells and can be blocked by BC96 and by TÜ69.Clone S20019C does not block the binding of clone S20019D and clone M-A251 on target cells.Clone S20019C can block IL-2 binding to receptor.Clone S20019C shows comparable CD25 staining on 4% formaldehyde-fixed cells compared to unfixed.

Host

Mouse

Reactivity

Human

Application

FC - Quality tested

Platform ID

BAB948269194

BioLegend

Headquarters

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NameSpark PLUS V475™ anti-human CD25 Antibody
Cat. No.385611
HostMouse
RRIDAB_3717137 (BioLegend Cat. No. 385611)AB_3717137 (BioLegend Cat. No. 385612)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberS20019C
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCD25
ImmunogenHuman CD25 transfected cells
PurityThe antibody was purified by affinity chromatography and conjugated with Spark PLUS V475™ under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD25 is a 55 kD transmembrane protein also known as interleukin-2 receptor alpha chain. CD25 in combination with CD122 and CD132 form a high affinity IL-2 receptor that binds to IL-2, playing a crucial role in activation of JAK1/JAK3 and STAT5 signaling. It is expressed on activated T-Cells as well as on CD4+ T regulatory cells, some progenitor B-cells and activated monocytes.

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