Spark Red™ 718 anti-human CD182 (CXCR2) (Flexi-Fluor™) Antibody, CD182, 5E8/CXCR2,BioLegend,285051

Additional reported applications (for the relevant formats) include: The 5E8/CXCR2 antibody is useful for immunofluorescent staining and flow cytometric analysis of CXCR2 expression.

Host

Mouse

Reactivity

Human

Application

FC

Platform ID

BAB192419532

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NameSpark Red™ 718 anti-human CD182 (CXCR2) (Flexi-Fluor™) Antibody, CD182, 5E8/CXCR2
Cat. No.285051
HostMouse
RRIDAB_3106313 (BioLegend Cat. No. 285051)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationFC
ClonalityMonoclonal
Clone Number5E8/CXCR2
Concentration0.2 mg/mL
TargetCD182
ImmunogenHuman CXCR2 transfected L1.2 cells
PurityThe antibody was purified by affinity chromatography and conjugated with Spark Red™ 718 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CXCR2 is a 67-70 kD seven-transmembrane protein, also known as IL-8 receptor B (IL-8RB), CD182, and CD128b. It is a CXC chemokine receptor belongs to G protein-coupled receptor (GPCR) family. CXCR2 is expressed as homodimer or heterodimer with CXCR1 and found on granulocytes, NK cells, subset of T lymphocytes, mast cells, monocytes, endothelial cells, megakarocytes, and oligodendrocytes. CXCR2 mediates neutrophil activation and chemotaxis, megakaryocytic proliferation, and angiogenesis via binding its ligands including IL-8(CXCL8), NAP-2(CXCL7), GCP-2(CXCL6), and GRO-α,β,γ (CXCL1, CXCL2, CXCL3).

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