Spark Red™ 718 anti-human CD8a Antibody, CD8a, S21010F,BioLegend,388806

Clone S21010F can completely block the binding of clone HIT8a, clone RPA-T8, and clone SK1 on target cells and can be blocked by HIT8a and SK1.Clone S21010F does not interfere with the binding of anti-human CD8β antibodies S21011A or QA20A40.Clone S21010F shows comparable staining signals on 4% paraformaldehyde-fixed cells and unfixed cells.

Host

Mouse

Reactivity

Human

Application

FC - Quality tested

Platform ID

BAB323956364

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Product Specifications
Scientific Background

Specifications

NameSpark Red™ 718 anti-human CD8a Antibody, CD8a, S21010F
Cat. No.388806
HostMouse
RRIDAB_3675117 (BioLegend Cat. No. 388805)AB_3675117 (BioLegend Cat. No. 388806)
IsotypeMouse IgG2b, κ
ReactivityHuman
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberS21010F
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCD8alpha
ImmunogenHuman CD8α-transfected cells
PurityThe antibody was purified by affinity chromatography and conjugated with Spark Red™ 718 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD8α, also known as T8 or Leu2, is a 32-34 kD type 1 transmembrane glycoprotein part of the immunoglobulin superfamily. CD8α is expressed on cytotoxic T cells, NK Cells, as well as a majority off thymocytes. CD8α can form a homodimer (CD8α/α) or heterodimer (CD8α/β) with CD8β. CD8α acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation, and has been shown to play a role in thymic differentiation. Two domains in CD8α are important for function: the extracellular Ig superfamily domain binds the α3 domain of MHC Class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.

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