Spark Red™ 718 anti-human TCR Vα24-Jαα18 (Flexi-Fluor™) Antibody, TCR Vα24-Jα18, 6B11,BioLegend,285220
The 6B11 antibody recognizes the invariant CDR3 region of TCR Va24-JaQ.
Host
Mouse
Reactivity
Human
Application
FC
Platform ID
BAB256999783
BioLegend
Contact
Tel: 1-858-455-9588
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Product Specifications
Scientific Background
Specifications
NameSpark Red™ 718 anti-human TCR Vα24-Jαα18 (Flexi-Fluor™) Antibody, TCR Vα24-Jα18, 6B11
Cat. No.285220
HostMouse
RRIDAB_3662456 (BioLegend Cat. No. 285220)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationFC
ClonalityMonoclonal
Clone Number6B11
Concentration0.2 mg/mL
TargetTCR Valpha24-Jalpha18
PurityThe antibody was purified by affinity chromatography and conjugated with Spark Red™ 718 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
Encoded by the TCR Vα24-Jα18 germline configuration, Vα24-JαQ is expressed on a subset of NKT cells, namely invariant NKT (iNKT). Vα24-JαQ TCR interacts with the glycolipid loaded MHC class 1b molecule CD1d, inducing activation and subsequent cytokine production. iNKT cells have been implicated in immune regulation, tumor surveillance, and host response to pathogens. While iNKT cells occur at low frequency in the blood, assorted chemokines contribute to their tissue homing potential.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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