Spark YG™ 570 anti-β-Amyloid, 17-24 Antibody, β-Amyloid, 17-24, 4G8,BioLegend,800721
This antibody is reactive to amino acid residues 17-24 of ß amyloid. The epitope lies within amino acids 18-22 of ß amyloid (VFFAE). 4G8 ß-amyloid antibody reacts to abnormally processed isoforms, as well as precursor forms.This antibody clone has been reported for use on IHC of free-floating sections in PBS containing 1% Triton incubated with 0.1 m citrate buffer (4).Additional reported applications (for the relevant formats) include: immunohistochemical staining on frozen tissue sections (IHC-F) and immunocytochemistry (ICC)
Host
Mouse
Reactivity
Human, Mouse
Application
IHC-P -Quality tested
Platform ID
BAB749253503
BioLegend
Contact
Tel: 1-858-455-9588
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Product Specifications
Scientific Background
Specifications
NameSpark YG™ 570 anti-β-Amyloid, 17-24 Antibody, β-Amyloid, 17-24, 4G8
Cat. No.800721
HostMouse
RRIDAB_2861075 (BioLegend Cat. No. 800721)AB_2861076 (BioLegend Cat. No. 800722)
IsotypeMouse IgG2b, κ
ReactivityHuman, Mouse
ApplicationIHC-P -Quality tested
ClonalityMonoclonal
Clone Number4G8
Targetbeta-Amyloid 17-24
PurityThe antibody was purified by affinity chromatography and conjugated with Spark YG™ 570 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
Alzheimer’s disease is characterized by the accumulation of aggregated Aβ peptides in senile plaques and vascular deposits. Aβ peptides are derived from amyloid precursor proteins (APP) through sequential proteolytic cleavage of APP by β-secretases and γ-secretases generating diverse Aβ species. Aβ can aggregate to form soluble oligomeric species and insoluble fibrillar or amorphous assemblies. Some forms of the aggregated peptides are toxic to neurons.
Category Paths
- Products>Primary Antibodies>IHC Antibodies
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