Stromal Interaction Molecule 1 Antibody (YA6222),MedChemexpress,HY-P86530

Stromal Interaction Molecule 1 Antibody (YA6222) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Stromal Interaction Molecule 1.

Host

Rabbit

Reactivity

Human,Mouse,Rat

Application

WB,IHC-P,ICC/IF,IP,ELISA

Conjugate

Non-conjugated

Platform ID

BAB851331150

Master of Bioactive Molecules

MedChemexpress

Master of Bioactive Molecules

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Tel: 609-228-6898
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Email:

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Product Specifications
Scientific Background
Synonyms

Specifications

NameStromal Interaction Molecule 1 Antibody (YA6222)
Cat. No.HY-P86530
Accession NumberQ13586
Gene ID (Entrez)6786
HostRabbit
IsotypeIgG
ReactivityHuman,Mouse,Rat
ConjugationNon-conjugated
ApplicationWB,IHC-P,ICC/IF,IP,ELISA
Working DilutionsIHC-P: 1:200-1:1000; WB: 1:1000-1:5000; ICC/IF: 1:200-1:1000; ELISA: 1:5000-1:20000; IP: 1:50-1:200
ClonalityMonoclonal
Clone NumberYA6222
Molecular WeightPredicted band size: 77 kDa; Observed band size: 77 kDa
PurityProtein A
Appearance/FormLiquid
ShippingShipping with blue ice.
FormulationSupplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
StorageStored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

Stromal Interaction Molecule 1 (STIM1) acts as a Ca2+ sensor that gates two major inward rectifying Ca2+ channels at the plasma membrane: Ca2+ release-activated Ca2+ (CRAC) channels and arachidonate-regulated Ca2+-selective (ARC) channels. It plays a key role in mediating store-operated Ca2+ entry (SOCE), a Ca2+ influx triggered by depletion of intracellular Ca2+ stores. Upon Ca2+ depletion, STIM1 translocates from the endoplasmic reticulum to the plasma membrane, where it activates CRAC channel pore-forming subunits ORA1, ORA2, and ORAI3 to generate sustained and oscillatory Ca2+ entry. Additionally, STIM1 is involved in enamel formation. by similar content includes: STIM1 activation mechanisms, interactions with ORAI subunits, and its roles in various cellular processes.

Synonyms

Stromal interaction molecule 1

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