Syk (4D10) Mouse Monoclonal Antibody (BSA and Azide Free)#81721,Cell Signaling Technology (CST),81721

Syk is a protein tyrosine kinase that plays an important role in intracellular signal transduction in hematopoietic cells (1-3). Syk interacts with immunoreceptor tyrosine-based activation motifs (ITAMs) located in the cytoplasmic domains of immune receptors (4). It couples the activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis (4). There is also evidence of a role for Syk in nonimmune cells and investigators have indicated that Syk is a potential tumor suppressor in human breast carcinomas (5). Tyr323 is a negative regulatory phosphorylation site within the SH2-kinase linker region in Syk. Phosphorylation at Tyr323 provides a direct binding site for the TKB domain of Cbl (6,7). Tyr352 of Syk is involved in the association of PLCγ1 (8). Tyr525 and Tyr526 are located in the activation loop of the Syk kinase domain; phosphorylation at Tyr525/526 of human Syk (equivalent to Tyr519/520 of mouse Syk) is essential for Syk function (9).Cheng, A.M. and Chan, A.C. (1997)Curr Opin Immunol9, 528-33.Kurosaki, T. (1997)Curr Opin Immunol9, 309-18.Chu, D.H. et al. (1998)Immunol Rev165, 167-80.Turner, M. et al. (2000)Immunol Today21, 148-54.Coopman, P.J. et al. (2000)Nature406, 742-7.Deckert, M. et al. (1998)J Biol Chem273, 8867-74.Rao, N. et al. (2001)EMBO J20, 7085-95.Law, C.L. et al. (1996)Mol Cell Biol16, 1305-15.Zhang, J. et al. (2000)J Biol Chem275, 35442-7.Alternate NamesDKFZp313N1010; FLJ25043; FLJ37489; KSYK; p72-Syk; spleen associated tyrosine kinase; Spleen tyrosine kinase; SYK; Tyrosine-protein kinase SYK

DKFZp313N1010; FLJ25043; FLJ37489; KSYK; p72-Syk; spleen associated tyrosine kinase; Spleen tyrosine kinase; SYK; Tyrosine-protein kinase SYK