Synaptophysin (D40C4) Rabbit Monoclonal Antibody#5467,Cell Signaling Technology (CST),5467

Synaptophysin (D40C4) Rabbit Monoclonal Antibody detects endogenous levels of total synaptophysin protein.

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

Western Blotting: 1:1000 Immunoprecipitation: 1:50

Platform ID

BAB384504758

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameSynaptophysin (D40C4) Rabbit Monoclonal Antibody#5467
Cat. No.5467
Accession NumberP08247
Gene ID (Entrez)08247, 6855
HostRabbit
SensitivityEndogenous
ReactivityHuman, Mouse, Rat
ApplicationWestern Blotting: 1:1000 Immunoprecipitation: 1:50
Molecular Weight38
ImmunogenIgG
FormulationSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
StorageSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Regulatory StatusResearch Use Only

Scientific Background

Synaptophysin (SYP) is a neuronal synaptic vesicle glycoprotein that is expressed in neuroendocrine cells and neoplasms (1). Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore (2). Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases (3). Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex (4).Wiedenmann, B. et al. (1986)Proc Natl Acad Sci USA83, 3500-4.Valtorta, F. et al. (2004)Bioessays26, 445-53.Arthur, C.P. and Stowell, M.H. (2007)Structure15, 707-14.Bonanomi, D. et al. (2007)Biochem J404, 525-34.Alternate NamesMajor synaptic vesicle protein p38; MRX96; MRXSYP; Synaptophysin; SYP; SYPH

Synonyms

Major synaptic vesicle protein p38; MRX96; MRXSYP; Synaptophysin; SYP; SYPH

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