Synaptophysin (D8F6H) Rabbit Monoclonal Antibody (BSA and Azide Free)#25056,Cell Signaling Technology (CST),25056

Synaptophysin (SYP) is a neuronal synaptic vesicle glycoprotein that is expressed in neuroendocrine cells and neoplasms (1). Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore (2). Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases (3). Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex (4).Wiedenmann, B. et al. (1986)Proc Natl Acad Sci USA83, 3500-4.Valtorta, F. et al. (2004)Bioessays26, 445-53.Arthur, C.P. and Stowell, M.H. (2007)Structure15, 707-14.Bonanomi, D. et al. (2007)Biochem J404, 525-34.Alternate NamesMajor synaptic vesicle protein p38; MRX96; MRXSYP; Synaptophysin; SYP; SYPH

Major synaptic vesicle protein p38; MRX96; MRXSYP; Synaptophysin; SYP; SYPH