Syntaxin 1A (D4E2W) Rabbit Monoclonal Antibody#18572,Cell Signaling Technology (CST),18572

Syntaxin 1A (STX1A) is a SNARE protein involved in intracellular membrane fusion, including synaptic vesicle fusion (1). At the synapse, syntaxin 1 is located at the presynaptic plasma membrane and is therefore categorized as a t-SNARE protein (2). The amino-terminal domain of syntaxin 1 interacts with Munc18-1 and this interaction is essential for synaptic vesicle fusion (3). Although originally characterized from neural tissues, research studies have demonstrated syntaxin 1A expression in exocrine tissues such as pancreatic islets (4) where it negatively regulates insulin release (5).Südhof, T.C. and Rothman, J.E. (2009)Science323, 474-7.Fukuda, R. et al. (2000)Nature407, 198-202.Zhou, P. et al. (2013)EMBO J32, 159-71.Jacobsson, G. et al. (1994)Proc Natl Acad Sci U S A91, 12487-91.Nagamatsu, S. et al. (1996)J Biol Chem271, 1160-5.Alternate NamesHPC-1; Neuron-specific antigen HPC-1; P35-1; STX1; STX1A; SYN1A; syntaxin 1A; syntaxin 1A (brain); Syntaxin-1A

HPC-1; Neuron-specific antigen HPC-1; P35-1; STX1; STX1A; SYN1A; syntaxin 1A; syntaxin 1A (brain); Syntaxin-1A