α-Synuclein Rabbit PolymAb®,ABclonal,A22598PM

Reactivity

Human, Mouse, Rat

Application

WB, IF/ICC, IF-F, IHC-P, ELISA

Conjugate

Unconjugated

Platform ID

BAB868784836

ABclonal

Headquarters

500W Cummings Park, Ste. 6500 Woburn, MA 01801

ABclonal

Contact

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Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Nameα-Synuclein Rabbit PolymAb®
Cat. No.A22598PM
Accession NumberP37840
Gene ID (Entrez)6622
IsotypeIgG
ReactivityHuman, Mouse, Rat
ConjugationUnconjugated
ApplicationWB, IF/ICC, IF-F, IHC-P, ELISA
Working DilutionsWB:1:500 - 1:1000 | IF/ICC:1:50 - 1:200 | IF-F:1:500 - 1:2000 | IHC-P:1:1000-1:5000 | ELISA:Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Molecular Weight18 kDa
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
PurityAffinity purification
Appearance/FormLiquid
StorageStore at -20℃. Avoid freeze / thaw cycles.; Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Regulatory StatusResearch Use Only

Scientific Background

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.

Synonyms

PD1; NACP; PARK1; PARK4

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